What is the Treatment for NOMID and Its Cost?

FDA-Approved Therapies, Alternative Treatments, and Cost Breakdown for NOMID

NOMID (Neonatal-Onset Multisystem Inflammatory Disease) is a sporadic disorder affecting approximately 100 people worldwide. It is the most severe form of cryopyrin-associated periodic syndromes (CAPS), characterised by skin rash, headaches, vomiting and seizures. Many people suffering from NOMID face joint inflammation, cartilage overgrowth and joint deformities. Medications such as anakinra and canakinumab can help manage this autoinflammatory disease.

What are the FDA-Approved Treatments for NOMID?

NOMID, also known as CINCA (Chronic Infantile Neurological Cutaneous and Articular syndrome), is mainly caused by CIAS1/NLRP3 gene mutation, resulting in an increased activity of interleukin (IL) 1ß. Anakinra and Canakinumab are the only drugs approved by the FDA to treat NOMID.

• Anakinra : It is a recombinant human interleukin-1 receptor antagonist (IL-1Ra) that blocks the production of interleukin by binding to the receptor. This medication is available as a subcutaneous injection that needs to be administered once daily. It has a half-life of 4-6 hours and helps manage symptoms such as brain inflammation, fever, joint pain, vision loss, hearing loss, and rash.  
• Canakinumab : It falls under the same drug class as anakinra (interleukin-1 inhibitor), but has a different mechanism of action. It is also approved by the FDA for treating NOMID. The drug is a monoclonal antibody that targets IL-1β (interleukin) and stops its activity altogether. It has a half-life of 26 days and is given every 2 months. 

Disclaimer: The treatments listed in this FAQ may or may not be approved in India. This content does not provide medical advice. For informational purposes only. 

What are Some Other Therapies for NOMID?

Apart from Anakinra and Canakinumab, doctors use several other approaches to manage the symptoms of NOMID. Let us discuss them below:

• Physical Therapy: NOMID symptoms often include pain, swelling and joint pain. To help relieve this, doctors suggest physical therapy for pain management and a better quality of life.
• NSAIDs: Nonsteroidal Anti-inflammatory Drugs are used initially to manage the symptoms of this disease. It helps relieve inflammation and reduce fever and other symptoms.

What are the NOMID Treatment Costs in India?

Treatment costs associated with NOMID may differ according to your doctor’s expertise and experience. It may also vary due to factors such as location.

● Cost of Medicine

Let us discuss the cost of medicine for NOMID in the table below:

Disclaimer: Do not consume these medicines without consulting a medical practitioner.

● Cost of Physiotherapy

Doctors also manage NOMID with physiotherapy. However, its cost can differ based on location. Physiotherapy costs in major metro cities are as follows:

Disclaimer: These prices can vary. Check with your physiotherapist for an accurate cost breakdown. 

● Cost of NSAIDs

NSAIDs are available both as over-the-counter and prescription medicines. Some common NSAIDs that reduce inflammation are as follows:

Disclaimer: Always consult a doctor before taking these for NOMID. 

Although NOMID has no cure, medical advancements have made the disease manageable. With early diagnosis and prompt medical support, people with this disease can achieve a better quality of life.