Have you ever felt unusually tired or noticed darkening of your skin without sun exposure? These could signal Addison’s disease, which is a rare but serious condition. It occurs when the immune system attacks the adrenal glands, reducing hormone production like cortisol and aldosterone. Early diagnosis and treatment can help manage symptoms and prevent complications.
Only 1 in 100,000 people is affected by Addison's disease. Besides autoimmunity, the most common cause, several other factors contribute to adrenal insufficiency:
Treatment of this disease focuses on replacing the deficient hormones. The two primary medications include:
These medications help manage symptoms and prevent adrenal crises. Regular monitoring and dosage adjustments are necessary during illness or stress.
People with Addison’s disease are often advised to consume a high-sodium diet, particularly during hot weather or physical exertion.
However, excessive potassium intake can worsen symptoms due to reduced aldosterone. As per NHS guidelines, foods to limit include:
A well-balanced diet rich in calcium and vitamin D (such as dairy, eggs, and fortified cereals) is beneficial for bone health, especially in those on long-term steroid therapy.
Due to aldosterone deficiency, some individuals with Addison's disease may need to be mindful of very high potassium intake. However, for most patients on proper fludrocortisone replacement, a normal, balanced diet is sufficient. It is important to have regular blood tests to monitor sodium and potassium levels, and any specific dietary restrictions should be discussed with a doctor or dietitian.
Without proper treatment, Addison's disease can lead to an adrenal crisis, which is a medical emergency. Some complications that it can lead to are:
An adrenal crisis is a life-threatening medical emergency caused by a severe deficiency of cortisol. It can be triggered by physical stress, infection, injury, or missing medication doses in a person with adrenal insufficiency.