Parathyroid hormone (PTH), produced by the parathyroid glands, regulates calcium and phosphorus levels in the blood. Though calcium is stored in bones, PTH maintains its blood levels. A deficiency can cause hypoparathyroidism, a rare but serious condition. According to the NIH, normal PTH levels range from 10 to 65 pg/mL and are measured via blood tests. Recognising PTH deficiency early is essential for effective treatment and prevention of complications.
Hypoparathyroidism is a rare condition where the parathyroid glands produce insufficient PTH, leading to low calcium and high phosphorus levels in the blood. Excess phosphorus further reduces calcium, potentially causing multiple health issues.
PTH also regulates calcium reabsorption in the kidneys by up-regulating TRPV5, particularly in the thick ascending loop of Henle, distal convoluted tubule (DCT), and collecting ducts. Although calcium is mainly stored in bones, the blood needs it for vital functions such as nerve signalling, heart rhythm, muscle contraction, bone strength, and blood clotting.
Here are the functions that calcium in your blood supports:
Low calcium levels in your blood, caused by a deficiency of parathyroid hormone, hinder your body’s ability to perform the above functions efficiently.
Between 23 and 37 cases of hypoparathyroidism are estimated to occur for every 100,000 people annually, according to a study published in The Journal of Clinical Endocrinology & Metabolism. The symptoms of hypoparathyroidism, caused by low PTH levels, include:
Along with regulating calcium and phosphorus levels, PTH also helps regulate vitamin D levels in your blood and bones. Hypoparathyroidism can sometimes result from or be worsened by vitamin D deficiency.
A study published in the Indian Journal of Endocrinology and Metabolism found that 91.2% of healthy adults over 50 in Northern India had significant vitamin D insufficiency. This deficiency may indirectly affect PTH levels and calcium absorption.
If you are experiencing the above symptoms of hypoparathyroidism, you should consult a doctor or healthcare provider. Based on the discussion, they may recommend certain diagnostic tests.
Doctors primarily use the parathyroid hormone blood test to confirm PTH deficiency. This test is commonly known as “PTH intact” among healthcare professionals. Additional tests to evaluate calcium, phosphorus, and vitamin D levels are also often conducted.
The goal of treatment is to manage the low calcium levels caused by PTH deficiency. This is done by:
Parathyroid hormone deficiency causes hypoparathyroidism, leading to low blood calcium levels and affecting nerves, muscles, heart, and bones. Treatment includes a calcium-rich diet, vitamin D and calcium supplements, or PTH injections. Early diagnosis and proper medical care are vital to prevent complications and manage the condition effectively.