Difference Between Small Cell and Non-Small Cell Lung Cancer?

Small Cell vs Non-Small Cell Lung Cancer: What’s the Difference?

Lung cancer remains one of the leading causes of cancer-related deaths worldwide, accounting for approximately 1 in 5 cancer fatalities, as reported by the World Health Organization (WHO). Among the various forms of lung cancer, 2 primary categories—small cell and non-small cell—comprise nearly all diagnosed cases.

Although both types originate in the lungs, they differ significantly in their development, progression, and response to treatment. Recognizing these differences is crucial for early diagnosis and effective care. With lung cancer affecting millions each year, understanding its types can lead to better outcomes and awareness.

Read ahead to learn the differences between small and non-small cell lung cancer.

What is Small Cell Lung Cancer (SCLC)?

Small cell lung cancer (SCLC) is a severe form of lung cancer, constituting about 10–15% of all lung cancer cases. It is primarily linked to smoking and tends to develop and spread quickly to other tissues in the body. Due to its rapid growth, SCLC is often diagnosed at an advanced stage, making treatment more challenging.

Surgery is rarely an option due to the widespread nature of the disease at diagnosis. Instead, treatment primarily involves chemotherapy and radiation therapy. Despite initial responsiveness to treatment, SCLC often recurs, requiring ongoing management.

What is Non-Small Cell Lung Cancer (NSCLC)?

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, accounting for 85–90% of cases. It includes adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. NSCLC generally grows and spreads more slowly than small cell lung cancer.

NSCLC can affect both smokers and non-smokers and often presents with subtle symptoms in the early stages. Diagnosis usually involves imaging techniques and biopsy. Treatment options vary and may include surgery, chemotherapy, radiation, targeted therapy, or immunotherapy, depending on the cancer stage.

How are SCLC and NSCLC Different?

Though both cancers originate in the lungs and may share symptoms, they differ in growth patterns, risk factors, prognosis, and treatment approaches. Here’s a detailed comparison to clarify these differences:

Understanding the differences between non-small and small cell lung cancer is crucial, as they vary in prevalence, growth rate, treatment strategies, and survival outcomes. Early and accurate diagnosis is essential to improve recovery chances, especially for NSCLC, which responds better when caught early.

Thus, it is crucial to have health insurance to secure your health and finances during critical times. Star Health's Cancer Care Gold Insurance Policy provides comprehensive coverage for cancer patients' diagnosis, treatment, hospitalization, and follow-up care, including SCLC and NSCLC. We also offer hassle-free claim settlements across over 14,000 network hospitals in India.