Difference Between Sustained Release and Extended Release Tablets
Extended Release vs Sustained Release - Drug Delivery Explained
People often use the two terms, sustained and extended release drugs, to describe how a drug gets released into the body. Though the formulation of these two drug types may sound similar, they serve different purposes.
What are Sustained-Release Tablets?
Sustained release (SR) is a specific drug formulation designed to release the active ingredient gradually over an extended period. This particular process allows a balanced concentration of the drug in the bloodstream.
SR formulations aim to prolong the drug’s action but may still allow for fluctuations in blood levels.
It helps increase the efficiency of those tablets and reduce the dosing frequency. SR formulations are helpful for medications that need to maintain a consistent level inside the body for optimal results.
What are Extended-Release Tablets?
Extended release (ER) tablets also slowly release their active ingredients over a longer period than SR. These medicines work over a longer period, releasing the drug throughout the entire day or night.
ER formulations are engineered to maintain a more stable concentration of the drug in the bloodstream over a longer period—sometimes up to 24 hours
ER formulations reduce the requirement for frequent dosing and ensure the maintenance of their effect over a longer duration. Doctors recommend these medications for chronic pain management or the treatment of cardiovascular conditions.
Key Differences Between Sustained Release and Extended Release Tablets
Here, we will discuss key differences between SR and ER medications based on certain features, like duration of release, dosage frequency, and absorption rate in the body:
| Features | Extended Release (ER) | Sustained Release (SR) |
| Duration of Release | These medications can last up to 24 hours inside the body. | SR medications typically last for 8-12 hours. |
| Dose Frequency | Generally, taken once a day, either before or after a meal. | Usually, it requires 2 or more doses per day. |
| Absorption Rate | Primarily, slower and prolonged release over a longer period. | These medicines are released gradually over several hours to achieve optimal effect. |
| Usage | Used for conditions that require 24-hour relief, like chronic pain. | Mainly requires conditions, like arthritis, to maintain steady drug levels. |
| Examples | Lorazepam, Hydrocortisone, Naloxone, and Morphine. | Bupropion, Alprazolam, Clomipramine, and Quetiapine. |
Benefits of ER and SR Tablets
Both of these formulations offer various benefits compared to regular immediate-release medications. These include:
- Better Convenience: You do not need to take multiple doses throughout the day if your doctor has prescribed SR or ER medications. These drugs increase patient compliance and help in managing the conditions effectively.
- Better Control of Symptoms: Both ER and SR formulations ensure a consistent level of the drug in physiological systems. This leads to better management of symptoms and does not hamper effectiveness.
- Minimal Side Effects: SR and ER medications prevent the rapid spikes in drug concentration that may occur with immediate-release versions. Thus, these formulations reduce side effects, such as dizziness, drowsiness, and nausea.
While choosing between extended-release and sustained-release drugs, it is important to consider the specific needs of your health condition. Both offer significant benefits in terms of symptom control, convenience, and reduced side effects. Always consult with your healthcare provider to decide the best treatment plans for your needs.
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