What are the Characteristics of End Stage Renal Disease?

End Stage Renal Disease Characteristics and All About It

End-stage renal disease (ESRD), or kidney failure, occurs when the kidneys lose nearly all their ability to filter waste from the blood. This final stage of chronic kidney disease severely impacts a person's health, leading to the accumulation of toxins, excess fluids, and imbalanced electrolytes. Understanding the characteristics of ESRD is necessary for timely diagnosis and treatment to stop further complications.

How to Determine the End-Stage Renal Disease? 

Here are the symptoms to understand its characteristics:

Symptom 1: Severe Fatigue and Weakness

• One of the first signs of ESRD is profound fatigue, which becomes increasingly difficult to manage. As the kidneys fail, toxins build up in the body, leading to a general sense of being unwell. This can also cause weakness and a lack of energy.

Symptom 2: Swelling (Oedema)

• Kidneys that can no longer filter fluids properly lead to fluid retention, causing swelling, particularly in the legs, ankles, feet, and sometimes the face. This condition is called oedema, and it worsens as the kidney function declines.

Symptom 3: Changes in Urination Patterns

• People with ESRD may see a drastic reduction in urine output or a complete cessation of urine production. The urine may also appear foamy or dark in colour. This is because the kidneys are not able to filter out the waste, resulting in a buildup of toxins in the body.

Symptom 4: Persistent Itching

• Waste products build up in the bloodstream, thus causing uremia and leading to severe itching (pruritus). Dry, irritated skin may accompany this, and the itching usually worsens as kidney failure progresses.

Symptom 5: Loss of Appetite and Weight Loss

• As ESRD progresses, many individuals experience a loss of appetite and significant unintended weight loss. This is due to the accumulation of unwanted waste products and toxins, which disrupt common and normal metabolic processes.

Complications and Long-Term Effects of End-Stage Renal Disease

Besides these visible symptoms, ESRD can result in a wide range of serious health complications. Some of these complications can majorly affect a patient's quality of life and require urgent medical intervention.

Complication 1: High Blood Pressure

Hypertension is both a cause and a consequence of kidney failure. ESRD can exacerbate high blood pressure, which in turn worsens kidney damage. Uncontrolled hypertension can lead to heart problems and strokes.

Complication 2: Anaemia

In ESRD, the kidneys no longer produce sufficient erythropoietin, a hormone that stimulates red blood cell generation. As a result, several patients develop anaemia, which shows symptoms such as dizziness, weakness, and pallor.

Complication 3: Bone Disease

Kidney failure affects calcium and phosphate balance, resulting in bone and mineral abnormalities. This condition could result in bone pain, fractures, and an increased risk of bone deformities due to weakened bones.

Complication 4: Pericarditis

As kidney function declines, fluid can build up around the heart, leading to inflammation of the heart's lining (pericarditis). It can cause chest pain, shortness of breath, and heart complications.

Treatment Options for End-Stage Renal Disease

Managing ESRD usually requires dialysis or a kidney transplant, depending on the patient's overall health and other individual factors. Dialysis helps manage the symptoms of kidney failure by filtering out waste and excess liquids from the blood, while a kidney transplant offers a potential long-term solution if a suitable donor kidney is available.

1. Dialysis: Hemodialysis and Peritoneal Dialysis

There are two main types of dialysis:

• Hemodialysis: Blood is filtered using an artificial kidney machine. This process is typically performed in a medical centre or hospital.
• Peritoneal Dialysis: A special solution is introduced into the abdomen to absorb waste products from the blood, which is then drained. This method can be done at home.

2. Kidney Transplant

• Surgeons surgically place a healthy kidney into the patient's body during a kidney transplant. They consider this procedure when dialysis no longer suffices or when dialysis severely impacts the patient's quality of life.

The end-stage renal disease presents a host of symptoms, including severe fatigue, swelling, changes in urination, and skin issues like itching. It leads to serious complications such as hypertension, anaemia, and bone disease. Early diagnosis and intervention, including dialysis or a kidney transplant, are crucial for managing ESRD and improving quality of life.

Also Read:

→ What are the diagnostic criteria for MELAS

→ What are the Different Stages of Diabetic Retinopathy

→ What are the Different Types of Aortic Aneurysms

→ What are the Symptoms of Paget’s Disease

→ What are the Three Types of AKI