Difference between Alzheimer's disease and Parkinson's disease
Alzheimer’s vs. Parkinson’s: Key Differences & Similarities Explained
Alzheimer’s disease and Parkinson’s disease both fall under the category of neurodegenerative conditions. Moreover, people affected by them show almost similar symptoms and may undergo the same treatment methodologies. However, there are a few differences.
What is Alzheimer’s Disease?
Commonly referred to as AD, it is a form of dementia. Therefore, it results in a progressive neurodegenerative disease characterized by amyloid plaques, neurofibrillary tau tangles, and hippocampal atrophy, leading to memory loss and cognitive decline. It covers aspects like memory, thinking, and even problem-solving capabilities.
What is Parkinson’s Disease?
Parkinson’s disease is a neurodegenerative disorder caused by dopaminergic neuron loss in the substantia nigra, leading to motor symptoms and non-motor features. Usually, this part of the brain is responsible for daily movements. However, PD can also cause nonmotor symptoms which impacts thinking, behaviour and memory.
Comparison Between Alzheimer’s Disease and Parkinson’s Disease
The table given below denotes both the similarities and differences between Parkinson’s disease and Alzheimer’s disease:
| Basis of Comparison | Parkinson’s Disease | Alzheimer’s Disease |
| Typical Age of Onset | Those developing Parkinson’s disease can be aged between 50-65 years. Some may get affected earlier. | AD generally develops after the mid-60s. |
| Main Symptom at Onset | People experience movement problems like rigidity in locomotory muscles, bradykinesia, tremors, etc. | The most common symptoms include memory loss and confusion. |
| Primary Cognitive Impact | Parkinson’s disease leads to diminished problem-solving abilities, poor speed of thinking and hampers mood. | Alzheimer’s disease mainly causes memory and language impairment. |
| Sleep Disorders | The patient is likely to experience active bodily movements while dreaming. | A person’s sleep quality deteriorates early in the disease. Therefore, they may feel restless at night and sleepy throughout the day. |
| Progression | Parkinson’s disease brings changes to the neurons gradually, which worsen one’s motor skills. | The symptoms spread steadily with more functional decline over the period. |
| Treatment Focus | Doctors arrange for motor symptom relief as there is no permanent cure. | Patients typically get cognitive support and seek symptom management, as there is no definite cure. |
| Risk Factors | Parkinson's disease may be triggered by environmental toxins, head trauma, age and genetics. | Some major risk factors are genetics, age, head injury and diabetes. |
Treatment of Alzheimer’s Disease
Neurologists can select from various medical treatments suitable for Alzheimer’s disease. These actions can slow down the disease progression for many individuals. However, they cannot reverse the impact of the disease.
Some medications that are proven to restrict Alzheimer’s disease symptoms are as follows:
- Aricept (donepezil)
- Exelon (rivastigmine)
- Namenda (memantine)
- Razadyne (galantamine)
- Leqembi (lecanemab)
Besides these medicines, your healthcare provider can recommend symptomatic treatments to contain some effects of the condition, such as agitation or depression.
Treatment of Parkinson’s Disease
There are no such medicines that can prevent the progression of Parkinson’s disease. However, when you consult a specialist, they provide you with:
- Parkinson’s Medications: These medications impact chemicals in your brain to prevent the progression of symptoms.
- Symptomatic Treatments: With these remedies, you cannot directly treat the disease. However, they act as a coping mechanism. For instance, your doctor can potentially suggest medical treatment for depression and constipation.
- Deep Brain Stimulation: For some Parkinson's patients, deep brain stimulation (DBS) involves surgically placing a device in the brain. It delivers electrical impulses to help regulate and improve motor control.
In the end, both Alzheimer’s and Parkinson’s diseases are not something very uncommon. People can develop these conditions as they age. The key will be to utilise all the available resources optimally to improve the nutrition, physical capabilities and overall quality of life.
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