Insulin secretion, insulin action, or both are affected by a long-term metabolic disorder called diabetes mellitus, resulting in hyperglycemia. It is a worldwide health issue with rising prevalence due to multiple genetic, lifestyle, and environmental factors. Therefore, knowledge of the risk factors for diabetes is crucial for prevention, early detection, and proper management.
Type 1, type 2, and gestational diabetes are the primary types of diabetes. Type 2 is the most common. These risk factors are associated with diabetes:
Genetic and Family History
Genetic susceptibility is crucial, especially in type 1 and type 2 diabetes. People with a history of diabetes in the family are at increased risk of developing the condition. For example, if the parents or one of the parents has type 2 diabetes, their offspring have an even higher risk of developing the same. Some genes, such as HLA-DR3 and HLA-DR4, are linked to type 1 diabetes. Ethnic origin also affects risk; individuals of South Asian, African-Caribbean, Hispanic, or Native American descent are at increased risk of type 2 diabetes.
Age
The risk of developing type 2 diabetes rises with increasing age, particularly after age 45. The changes occurring with age that contribute to insulin resistance include loss of muscle mass, weight gain, and a decrease in physical activity. Type 1 diabetes tends to occur in children and adolescents but may develop at any age.
Overweight and Obesity
One of the strongest modifiable risk factors for type 2 diabetes is being overweight, especially central obesity (fat around the belly). Fat tissue, particularly visceral fat, disrupts insulin's controlling role over blood sugar levels and causes insulin resistance. Furthermore, research indicates that overweight people are several times more likely to develop type 2 diabetes than those with a healthy body mass index (BMI).
Physical Inactivity
A sedentary lifestyle has a strong link with type 2 diabetes. Exercise maintains weight, burns off glucose for energy, and increases insulin sensitivity. Inactivity leads to weight gain and enhances the risk of metabolic syndrome, a group of conditions that increase the risk of developing cardiovascular diseases and diabetes.
Poor Diet
Eating a high intake of refined carbohydrates, sugars, saturated fats, and processed foods may result in obesity and insulin resistance. On the other hand, eating a high intake of whole grains, fruits, vegetables, lean proteins, and healthy fats can help decrease the risk. Furthermore, high consumption of sugary drinks and fast food is especially associated with rising diabetes rates among youth.
Insulin resistance causes hypertension and dyslipidemia (high triglycerides and low HDL or "good" cholesterol). These health issues impair blood vessel function and insulin function, contributing to the development of type 2 diabetes.
Women diagnosed with gestational diabetes during pregnancy are more likely to develop type 2 diabetes later in life. In addition, the delivery of a baby weighing above 4 kg (9 lbs) increases the risk of diabetes in the mother.
Sleep Patterns and Stress
Poor sleep quality, abnormal sleep patterns, and chronic stress negatively affect insulin sensitivity. Cortisol, a stress hormone, raises blood glucose and stimulates fat storage. Moreover, chronic stress and sleep deprivation are risk factors for diabetes.
Smoking and Alcohol Use
Smoking cigarettes is associated with insulin resistance, belly fat accumulation, and an increased risk of type 2 diabetes. Excessive intake of alcohol will also interfere with liver and insulin function, though moderate consumption has had mixed impacts based on various health profiles.
PCOS causes impaired glucose metabolism. It leads to hormonal imbalances, irregular menstrual cycles, and weight gain. Women with PCOS are at an increased risk of developing insulin resistance and, therefore, type 2 diabetes.
Henceforth, genetic, behavioural, and environmental factors contribute to diabetes. While certain risk factors, including genetics and age, are non-modifiable, many lifestyle-related risk factors can be managed through diet, physical activity, weight control, and health check-ups.
Public health initiatives focusing on increasing awareness, encouraging healthier lifestyles, and enhancing access to preventive care are essential in mitigating diabetes. Therefore, communities and individuals can strive for reduced incidence and improved diabetes control by identifying and reducing risk factors.