India is fast emerging as a hub for innovative treatments by using nanomedicine in practice. Nanoparticle drug delivery is an innovative technique that uses particles thousands of times smaller than a grain of sand to deliver medications with pinpoint accuracy. By targeting specific cells, this method can enhance effectiveness and may reduce side effects compared to conventional drug delivery, though results vary by treatment type.
Understanding Nanoparticle Drug Delivery
Nanoparticle drug delivery is a method where tiny particles, generally smaller than 100 nanometres, are used to carry medicines directly to specific areas of the body. They help improve the effectiveness of a drug by enhancing its absorption and protecting it from breaking down too early. This potentially reduces any side effects of drug delivery.
A targeted approach like nanoparticle drug delivery is being explored in areas such as gene therapy and cancer treatment, with some approved applications and many still under clinical research.
Cost of Nanoparticle Drug Delivery in India
This modern form of drug delivery system has significantly higher costs associated with it. Here is an overview of the costs of nanoparticle drug delivery in India for some treatments and procedures:
Types of Treatment
Estimated Costs
Abraxane (100 mg vial)
₹13,000 – ₹18,000
Zolgensma (SMA gene therapy)
₹16,00,00,000 – ₹18,00,00,000
mRNA COVID-19 booster (private)
₹2,000 – ₹2,500 per dose
Please note that these prices are taken from various sources.
Popular Applications of Nanoparticle Drug Delivery
Nanoparticle drug delivery system has a very vast range of applications across different fields, including:
Gene Therapy- Nanoparticles can carry genetic material such as RNA or DNA into cells. It enables the treatment of genetic disorders and gene editing.
Cancer Treatment- Nanoparticles are used to deliver chemotherapy drugs directly to the tumour cells. It reduces any adverse side effects.
Antibiotics and Antimicrobials- Antibiotics and antimicrobial agents are delivered to infected sites with nanoparticles. It improves their effectiveness and reduces the risk of developing antibiotic resistance.
Vaccines - Nanoparticles help with the delivery of mRNA and protein-based vaccines. It enhances the immune responses while actively reducing the need for any adjuvants.
What are the Benefits of Nanoparticle Drug Delivery?
Here are some of the benefits of nanoparticle-induced medicines:
Targeted Drug Delivery System : Nanoparticles are engineered to deliver drugs specifically to the affected cells (cancer cells) and reduce harm to the healthy cells.
Improved Bioavailability : Nanoparticles enhance the solubility and absorption of poorly soluble drugs, which leads to better therapeutic outcomes.
Crossing Biological Barriers : Nanoparticle drugs can cross complex barriers like the blood-brain barrier. It enables the treatment of neurological disorders.
Protection of Drug Molecules : An encapsulation in nanoparticles protects sensitive drugs like siRNA or peptides from degradation before reaching their target.
Risks and Challenges of Nanoparticle Drug Delivery
Here is a list of some of the risks and challenges of nanoparticle drug delivery:
Toxicity and Biocompatibility : Some nanoparticles are toxic and cause inflammation, immune responses or oxidative stress if they accumulate in the organs.
Unknown Long-Term Effects : Chronic exposure to nanoparticles is not yet fully understood. Research is still going on in that field.
Cost and Manufacturing Complexity : Production and scaling of nanoparticle drugs are complex, expensive and vary between batches.
Nanoparticle drug delivery is a transformative advancement in the field of medicine. It offers safer treatment options for a wide range of diseases. With ongoing research, nanomedicine holds the potential to redefine the future of healthcare worldwide.
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